Journal article
Safety and immunogenicity of the 23-valent pneumococcal polysaccharide vaccine at 12 months of age, following one, two, or three doses of the 7-valent pneumococcal conjugate vaccine in infancy
FM Russell, PV Licciardi, A Balloch, V Biaukula, L Tikoduadua, JR Carapetis, J Nelson, AWJ Jenney, L Waqatakirewa, S Colquhoun, YB Cheung, MLK Tang, EK Mulholland
Vaccine | ELSEVIER SCI LTD | Published : 2010
Abstract
Fijian infants aged 6 weeks were stratified by ethnicity and randomized to receive 0, 1, 2, or 3 PCV-7 doses with or without the 23-valent pneumococcal polysaccharide vaccine (PPV-23) at 12 months. Strong booster effects for all 7 PCV-7 serotypes were elicited, and for 4/7 serotypes these responses were highest in the single PCV-7 group. There were fourfold rises in GMC for all non-PCV-7 serotypes. By 17 months the PPV-23 group still had significantly higher GMC (each p < 0.001) for all serotypes. The PPV-23 was well tolerated and induced excellent responses for all serotypes which were greatest in the single PCV-7 group. © 2010 Elsevier Ltd.
Grants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
The authors wish to sincerely thank all the FiPP staff and families participating in the study, the Fiji Ministry of Health, CWMH laboratory and paediatric department, and the many other people who contributed to the study including: Amanda O'Brien, Kathryn Bright, Amy Bin Chen, Timothy Gemetzis, Amy Auge, Katherine Gilbert, Evan Willis, Philip Greenwood, Beth Temple, Vanessa Johnston, Loretta Thorn, Porter Anderson, Brian Greenwood, George Siber, David Klein, Elizabeth Horigan, Farukh Khambaty, and the members of the DSMB. Funding was provided by the U.S. NIAID (grant number RO1 AI 52337) and the Australian National Health and Medical Research Council. Pneumovax (TM) was kindly donated by CSL Biotherapies, Australia. The co-administered Tritanrix (TM)-HepB (TM) and Hiberix (TM) vaccines were kindly donated by GlaxoSmithKline. Clinicaltrials.gov number NCT00170612.